Impact of Abnormal Potassium on Arrhythmia Risk During Pediatric Digoxin Therapy

Digoxin is used in children with heart failure and tachyarrhythmia. Its use in patients with single ventricle anatomy has increased following evidence of improved interstage survival after the Norwood procedure. Digoxin has a narrow therapeutic window and may alter serum potassium balance, inducing...

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Veröffentlicht in:	Pediatric cardiology 2024-04, Vol.45 (4), p.901-908
Hauptverfasser:	Mlambo, Vongai Christine, Algaze, Claudia A., Mak, Kwai, Collins, R. Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Arrhythmias, Cardiac - chemically induced Arrhythmias, Cardiac - drug therapy Cardiac Surgery Cardiology Child Digoxin - adverse effects Humans Medicine Medicine & Public Health Norwood Procedures - adverse effects Potassium Tachycardia - drug therapy Vascular Surgery
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Zusammenfassung:	Digoxin is used in children with heart failure and tachyarrhythmia. Its use in patients with single ventricle anatomy has increased following evidence of improved interstage survival after the Norwood procedure. Digoxin has a narrow therapeutic window and may alter serum potassium balance, inducing arrhythmias. We hypothesized digoxin use in the setting of abnormal serum potassium levels is associated with arrhythmias. We reviewed all patients ≤ 18 years who received digoxin while admitted at our institution from 2014 to 2021. Admissions
ISSN:	0172-0643 1432-1971
DOI:	10.1007/s00246-022-03051-3