Effect of phytic acid on dentinal collagen solubilization and its binding and debinding potentials to dentin
•Phytic acid effect on collagen solubilization was studied and compared to phosphoric acid.•Overall hydroxyproline release induced by phytic acid was lower compared to phosphoric acid.•Phytic acid has the ability to bind to mineralized and demineralized dentin.•Phytic acid debound from mineralized d...
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| Veröffentlicht in: | Journal of dentistry 2023-01, Vol.128, p.104361-104361, Article 104361 |
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| container_title | Journal of dentistry |
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| creator | Forgione, Diletta Nassar, Mohannad Seseogullari-Dirihan, Roda Jamleh, Ahmed Tezvergil-Mutluay, Arzu |
| description | •Phytic acid effect on collagen solubilization was studied and compared to phosphoric acid.•Overall hydroxyproline release induced by phytic acid was lower compared to phosphoric acid.•Phytic acid has the ability to bind to mineralized and demineralized dentin.•Phytic acid debound from mineralized dentin mostly by the action of urea.•Phytic acid debound from demineralized dentin mostly by the action of ethanol.
To study phytic acid (IP6) effect on collagen solubilization by assessing hydroxyproline (HYP) release, evaluate its binding to demineralized (DD) and mineralized dentin (MD) and determine the effect of different media on debinding of IP6.
Demineralized dentin beams were incubated in 1%, 2% or 3% IP6 and HYP release was evaluated at 1 or 3 weeks and compared to those obtained in untreated control or phosphoric acid (PA)-treated beams. DD or MD powder was treated with 1%, 2% or 3% IP6 and the decrease in IP6 amount was quantitated by ultraviolet–visible spectroscopy. IP6-treated samples were re-suspended in distilled water, ethanol, urea or sodium chloride and the amount of IP6 displaced was determined.
At 1 week, the control group and IP6 showed lower HYP release when compared to PA (P < 0.05). There was no difference among PA, IP6 and control at 3 weeks (P = 0.22). IP6 binding was concentration dependent. 1% IP6 had higher binding potential with MD compared to DD while 2% IP6 showed the opposite result (P |
| doi_str_mv | 10.1016/j.jdent.2022.104361 |
| format | Article |
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To study phytic acid (IP6) effect on collagen solubilization by assessing hydroxyproline (HYP) release, evaluate its binding to demineralized (DD) and mineralized dentin (MD) and determine the effect of different media on debinding of IP6.
Demineralized dentin beams were incubated in 1%, 2% or 3% IP6 and HYP release was evaluated at 1 or 3 weeks and compared to those obtained in untreated control or phosphoric acid (PA)-treated beams. DD or MD powder was treated with 1%, 2% or 3% IP6 and the decrease in IP6 amount was quantitated by ultraviolet–visible spectroscopy. IP6-treated samples were re-suspended in distilled water, ethanol, urea or sodium chloride and the amount of IP6 displaced was determined.
At 1 week, the control group and IP6 showed lower HYP release when compared to PA (P < 0.05). There was no difference among PA, IP6 and control at 3 weeks (P = 0.22). IP6 binding was concentration dependent. 1% IP6 had higher binding potential with MD compared to DD while 2% IP6 showed the opposite result (P<0.05). 3% IP6 had similar binding values between DD and MD (P = 0.53). The highest debinding in MD occurred with urea for 2%, 3% and 1% IP6 in descending manner. Within each concentration of IP6 in DD, the highest debinding effect was reported with ethanol.
IP6 bound to DD and MD in a concentration-dependent manner. IP6 was debound from DD mostly by the action of ethanol, while in MD, urea caused the most displacement. Collagen solubilization of IP6-treated DD was comparable to untreated DD.
These findings add to the potential use of IP6 as an alternative to PA for dentin etching which possibly results in long-term stability of resin-dentin adhesion.</description><identifier>ISSN: 0300-5712</identifier><identifier>EISSN: 1879-176X</identifier><identifier>DOI: 10.1016/j.jdent.2022.104361</identifier><identifier>PMID: 36379300</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Acids ; Binder removal ; Binding ; Collagen ; Collagen - chemistry ; Composite materials ; Debinding ; Demineralizing ; Dentin ; Dentistry ; Distilled water ; Enamel ; Etching ; Ethanol ; Ethanol - pharmacology ; Evaluation ; Hydroxyproline ; Phosphoric acid ; Phytic acid ; Phytic Acid - pharmacology ; Proteins ; Sodium chloride ; Solubilization ; Spectroscopy ; Urea ; Ureas</subject><ispartof>Journal of dentistry, 2023-01, Vol.128, p.104361-104361, Article 104361</ispartof><rights>2022 Elsevier Ltd</rights><rights>Copyright © 2022 Elsevier Ltd. All rights reserved.</rights><rights>2022. Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c317t-a95b645d5c7b43a4ffffc7e5b4a9a73dd52ba7227672e448114a1727bd7b67c03</citedby><cites>FETCH-LOGICAL-c317t-a95b645d5c7b43a4ffffc7e5b4a9a73dd52ba7227672e448114a1727bd7b67c03</cites><orcidid>0000-0002-0848-0737</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0300571222004134$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36379300$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Forgione, Diletta</creatorcontrib><creatorcontrib>Nassar, Mohannad</creatorcontrib><creatorcontrib>Seseogullari-Dirihan, Roda</creatorcontrib><creatorcontrib>Jamleh, Ahmed</creatorcontrib><creatorcontrib>Tezvergil-Mutluay, Arzu</creatorcontrib><title>Effect of phytic acid on dentinal collagen solubilization and its binding and debinding potentials to dentin</title><title>Journal of dentistry</title><addtitle>J Dent</addtitle><description>•Phytic acid effect on collagen solubilization was studied and compared to phosphoric acid.•Overall hydroxyproline release induced by phytic acid was lower compared to phosphoric acid.•Phytic acid has the ability to bind to mineralized and demineralized dentin.•Phytic acid debound from mineralized dentin mostly by the action of urea.•Phytic acid debound from demineralized dentin mostly by the action of ethanol.
To study phytic acid (IP6) effect on collagen solubilization by assessing hydroxyproline (HYP) release, evaluate its binding to demineralized (DD) and mineralized dentin (MD) and determine the effect of different media on debinding of IP6.
Demineralized dentin beams were incubated in 1%, 2% or 3% IP6 and HYP release was evaluated at 1 or 3 weeks and compared to those obtained in untreated control or phosphoric acid (PA)-treated beams. DD or MD powder was treated with 1%, 2% or 3% IP6 and the decrease in IP6 amount was quantitated by ultraviolet–visible spectroscopy. IP6-treated samples were re-suspended in distilled water, ethanol, urea or sodium chloride and the amount of IP6 displaced was determined.
At 1 week, the control group and IP6 showed lower HYP release when compared to PA (P < 0.05). There was no difference among PA, IP6 and control at 3 weeks (P = 0.22). IP6 binding was concentration dependent. 1% IP6 had higher binding potential with MD compared to DD while 2% IP6 showed the opposite result (P<0.05). 3% IP6 had similar binding values between DD and MD (P = 0.53). The highest debinding in MD occurred with urea for 2%, 3% and 1% IP6 in descending manner. Within each concentration of IP6 in DD, the highest debinding effect was reported with ethanol.
IP6 bound to DD and MD in a concentration-dependent manner. IP6 was debound from DD mostly by the action of ethanol, while in MD, urea caused the most displacement. Collagen solubilization of IP6-treated DD was comparable to untreated DD.
These findings add to the potential use of IP6 as an alternative to PA for dentin etching which possibly results in long-term stability of resin-dentin adhesion.</description><subject>Acids</subject><subject>Binder removal</subject><subject>Binding</subject><subject>Collagen</subject><subject>Collagen - chemistry</subject><subject>Composite materials</subject><subject>Debinding</subject><subject>Demineralizing</subject><subject>Dentin</subject><subject>Dentistry</subject><subject>Distilled water</subject><subject>Enamel</subject><subject>Etching</subject><subject>Ethanol</subject><subject>Ethanol - pharmacology</subject><subject>Evaluation</subject><subject>Hydroxyproline</subject><subject>Phosphoric acid</subject><subject>Phytic acid</subject><subject>Phytic Acid - pharmacology</subject><subject>Proteins</subject><subject>Sodium chloride</subject><subject>Solubilization</subject><subject>Spectroscopy</subject><subject>Urea</subject><subject>Ureas</subject><issn>0300-5712</issn><issn>1879-176X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kT1rHDEQhkVIsC-Of0EgCNK42Yu-VnNbuDDGTgIGNzakE_paR8uedF5pA86vj9Z3dpHC0wwzeuYVMy9CnylZU0Llt2E9OB_LmhHGakdwSd-hFd1A11CQv96jFeGENC1Qdow-5jwQQgRh3RE65pJDVx9XaLzqe28LTj3e_X4qwWJtg8Mp4kU7RD1im8ZRP_iIcxpnE8bwV5dQAR0dDiVjE6IL8eG5dv6l2qWyCOgx45IOYp_Qh742_Okhn6D766u7yx_Nze33n5cXN43lFEqju9ZI0brWghFci76GBd8aoTsN3LmWGQ2MgQTmhdhQKjQFBsaBkWAJP0Fne93dlB5nn4vahmx9XSP6NGfFgAOlHe-gol__Q4c0T3XthWqlbDeSskrxPWWnlPPke7WbwlZPT4oStZihBvVshlrMUHsz6tSXg_Zstt69zrxcvwLne8DXY_wJflLZBh-td2GqpiiXwpsf_APLnJwt</recordid><startdate>202301</startdate><enddate>202301</enddate><creator>Forgione, Diletta</creator><creator>Nassar, Mohannad</creator><creator>Seseogullari-Dirihan, Roda</creator><creator>Jamleh, Ahmed</creator><creator>Tezvergil-Mutluay, Arzu</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QP</scope><scope>7QQ</scope><scope>7SE</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8G</scope><scope>JG9</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0848-0737</orcidid></search><sort><creationdate>202301</creationdate><title>Effect of phytic acid on dentinal collagen solubilization and its binding and debinding potentials to dentin</title><author>Forgione, Diletta ; Nassar, Mohannad ; Seseogullari-Dirihan, Roda ; Jamleh, Ahmed ; Tezvergil-Mutluay, Arzu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c317t-a95b645d5c7b43a4ffffc7e5b4a9a73dd52ba7227672e448114a1727bd7b67c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Acids</topic><topic>Binder removal</topic><topic>Binding</topic><topic>Collagen</topic><topic>Collagen - chemistry</topic><topic>Composite materials</topic><topic>Debinding</topic><topic>Demineralizing</topic><topic>Dentin</topic><topic>Dentistry</topic><topic>Distilled water</topic><topic>Enamel</topic><topic>Etching</topic><topic>Ethanol</topic><topic>Ethanol - pharmacology</topic><topic>Evaluation</topic><topic>Hydroxyproline</topic><topic>Phosphoric acid</topic><topic>Phytic acid</topic><topic>Phytic Acid - pharmacology</topic><topic>Proteins</topic><topic>Sodium chloride</topic><topic>Solubilization</topic><topic>Spectroscopy</topic><topic>Urea</topic><topic>Ureas</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Forgione, Diletta</creatorcontrib><creatorcontrib>Nassar, Mohannad</creatorcontrib><creatorcontrib>Seseogullari-Dirihan, Roda</creatorcontrib><creatorcontrib>Jamleh, Ahmed</creatorcontrib><creatorcontrib>Tezvergil-Mutluay, Arzu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of dentistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Forgione, Diletta</au><au>Nassar, Mohannad</au><au>Seseogullari-Dirihan, Roda</au><au>Jamleh, Ahmed</au><au>Tezvergil-Mutluay, Arzu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of phytic acid on dentinal collagen solubilization and its binding and debinding potentials to dentin</atitle><jtitle>Journal of dentistry</jtitle><addtitle>J Dent</addtitle><date>2023-01</date><risdate>2023</risdate><volume>128</volume><spage>104361</spage><epage>104361</epage><pages>104361-104361</pages><artnum>104361</artnum><issn>0300-5712</issn><eissn>1879-176X</eissn><abstract>•Phytic acid effect on collagen solubilization was studied and compared to phosphoric acid.•Overall hydroxyproline release induced by phytic acid was lower compared to phosphoric acid.•Phytic acid has the ability to bind to mineralized and demineralized dentin.•Phytic acid debound from mineralized dentin mostly by the action of urea.•Phytic acid debound from demineralized dentin mostly by the action of ethanol.
To study phytic acid (IP6) effect on collagen solubilization by assessing hydroxyproline (HYP) release, evaluate its binding to demineralized (DD) and mineralized dentin (MD) and determine the effect of different media on debinding of IP6.
Demineralized dentin beams were incubated in 1%, 2% or 3% IP6 and HYP release was evaluated at 1 or 3 weeks and compared to those obtained in untreated control or phosphoric acid (PA)-treated beams. DD or MD powder was treated with 1%, 2% or 3% IP6 and the decrease in IP6 amount was quantitated by ultraviolet–visible spectroscopy. IP6-treated samples were re-suspended in distilled water, ethanol, urea or sodium chloride and the amount of IP6 displaced was determined.
At 1 week, the control group and IP6 showed lower HYP release when compared to PA (P < 0.05). There was no difference among PA, IP6 and control at 3 weeks (P = 0.22). IP6 binding was concentration dependent. 1% IP6 had higher binding potential with MD compared to DD while 2% IP6 showed the opposite result (P<0.05). 3% IP6 had similar binding values between DD and MD (P = 0.53). The highest debinding in MD occurred with urea for 2%, 3% and 1% IP6 in descending manner. Within each concentration of IP6 in DD, the highest debinding effect was reported with ethanol.
IP6 bound to DD and MD in a concentration-dependent manner. IP6 was debound from DD mostly by the action of ethanol, while in MD, urea caused the most displacement. Collagen solubilization of IP6-treated DD was comparable to untreated DD.
These findings add to the potential use of IP6 as an alternative to PA for dentin etching which possibly results in long-term stability of resin-dentin adhesion.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>36379300</pmid><doi>10.1016/j.jdent.2022.104361</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-0848-0737</orcidid></addata></record> |
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| ispartof | Journal of dentistry, 2023-01, Vol.128, p.104361-104361, Article 104361 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acids Binder removal Binding Collagen Collagen - chemistry Composite materials Debinding Demineralizing Dentin Dentistry Distilled water Enamel Etching Ethanol Ethanol - pharmacology Evaluation Hydroxyproline Phosphoric acid Phytic acid Phytic Acid - pharmacology Proteins Sodium chloride Solubilization Spectroscopy Urea Ureas |
| title | Effect of phytic acid on dentinal collagen solubilization and its binding and debinding potentials to dentin |
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