Verteporfin inhibits the dedifferentiation of tubular epithelial cells via TGF-β1/Smad pathway but induces podocyte loss in diabetic nephropathy

The dedifferentiation of tubular epithelial cells has been identified as an important trigger of renal fibrosis. The Hippo pathway is a crucial regulator of cell proliferation and differentiation. In this study, we determined the role of Hippo proteins in tubular dedifferentiation in diabetic nephro...

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Veröffentlicht in:	Life sciences (1973) 2022-12, Vol.311 (Pt B), p.121186-121186, Article 121186
Hauptverfasser:	Qi, Chenyang, Hu, Yuan, Zeng, Mingyao, Chen, Hongru, Shi, Jiaoyu, Jue, Hao, Zhao, Zhonghua, Liu, Jun, Zhang, Zhigang, Xu, Yanyong, Wu, Huijuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals apoptosis cadherins cell proliferation Dedifferentiation Diabetes Mellitus Diabetic Nephropathies - metabolism Diabetic nephropathy epithelium fibrosis glucose Hippo pathway Large tumor suppressor kinases 1 Mice neoplasms Podocytes - metabolism Protein Serine-Threonine Kinases Smad Proteins - metabolism therapeutics Transforming Growth Factor beta1 - metabolism Verteporfin Verteporfin - pharmacology Verteporfin - therapeutic use
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