Fibrinogen Levels and Total Serum Bile Acids in Intrahepatic Cholestasis of Pregnancy

Objective: To determine the role of complete blood count and coagulation function factors as inflammatory markers in intrahepatic cholestasis of pregnancy (ICP). Study Design: Descriptive, analytical study. Place and Duration of Study: Department of Obstetrics and Gynecology, Bursa Yuksek ihtisas Training and Research Hospital, Bursa, Turkey, between January 2018 and 2021. Methodology: This study was conducted with a total of 200 pregnant women, 80 with ICP and 120 control healthy pregnant women. The diagnosis of ICP was made based on elevated liver enzymes and bile acids ([greater than or equal to] 10 [micro]mol/L) and pruritis. Routine complete blood count parameters and coagulation function tests were compared between both groups. ROC analyses were used to analyse the predictive value of fibrinogen levels in ICP. Spearman's rank correlation analysis assessed the correlation between fasting bile acid value and complete blood count and coagulation parameters. Results: Neutrophil-lymphocyte ratio (NLR), Platelet count, and Platecrit levels were significantly higher in the ICP group, and red blood cell distribution width (RDW) was lower than in the healthy group (p