Role of C‐type natriuretic peptide in polycystic ovary syndrome

Objective To evaluate serum C‐type natriuretic peptide (CNP) and androgen concentrations in women with polycystic ovary syndrome (PCOS), and compare them with the healthy group. Methods The present study was carried out prospectively at the Near East University Hospital, between July 15, 2019 and September 1, 2020. Out of the 90 patients aged between 18 and 40 years old who were enrolled, the final study population consisted of 36 patients with PCOS and 30 healthy women. Results Body mass index, free androgen index, serum androstenedione, total testosterone, free testosterone, and CNP were significantly higher and serum sex‐hormone‐binding globulin level was lower in the PCOS group. Conclusion We revealed that serum CNP levels are high in PCOS patients. The mechanism of the relationship between this increase and hyperandrogenism or anovulation is not known, but these findings provide a direction for new studies. ClinicalTrials.gov NCT04006171. Synopsis C‐type natriuretic peptide, which was also found to be secreted from granulosa cells in the ovary, may play a role in polycystic ovary syndrome.