Synthesis and anti-ovarian cancer effects of benzimidazole-2-substituted pyridine and phenyl propenone derivatives

Given the benzimidazole derivatives have anti-ovarian cancer effects, the authors aimed to determine whether benzimidazole-2-substituted pyridine and phenyl propenone derivatives exert anti-ovarian cancer activity. 21 derivatives were synthesized and assayed for their antiproliferative activities. W...

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Veröffentlicht in:	Future medicinal chemistry 2022-12, Vol.14 (24), p.1835-1846
Hauptverfasser:	Cui, A-Long, Zhou, Zi-Ying, Wang, Ya-Li, Wu, Lin-Tao, Xue, Si-Tu, Li, Zhuo-Rong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use antiproliferative effect Apoptosis apoptosis-related proteins benzimidazole Benzimidazoles - pharmacology Cell Line, Tumor Cell Proliferation Female Humans Mice ovarian cancer Ovarian Neoplasms - drug therapy Ovarian Neoplasms - pathology pyridine and phenyl propenone Pyridines - pharmacology Pyridines - therapeutic use structure–activity relationships
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