Synthesis and anti-ovarian cancer effects of benzimidazole-2-substituted pyridine and phenyl propenone derivatives
Given the benzimidazole derivatives have anti-ovarian cancer effects, the authors aimed to determine whether benzimidazole-2-substituted pyridine and phenyl propenone derivatives exert anti-ovarian cancer activity. 21 derivatives were synthesized and assayed for their antiproliferative activities. W...
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Veröffentlicht in: | Future medicinal chemistry 2022-12, Vol.14 (24), p.1835-1846 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Given the benzimidazole derivatives have anti-ovarian cancer effects, the authors aimed to determine whether benzimidazole-2-substituted pyridine and phenyl propenone derivatives exert anti-ovarian cancer activity.
21 derivatives were synthesized and assayed for their antiproliferative activities. Western blotting in A2780 cells was used to detect the effects of compound A-6 on apoptosis-related proteins. Invasion, migration and apoptosis were assayed in SKOV3 cells treated with A-6. The
activity was also examined.
A-6 could inhibit proliferation, invasion and migration and induce apoptosis in SKOV3 cells. Additionally, A-6 had potent inhibitory activity in a xenograft mouse model.
A-6 shows potent efficacy in the treatment of ovarian cancer and may be a potential antitumor agent.
The benzimidazole-2-substituted pyridine propenone derivative A-6 shows potent activity against ovarian cancer
and
and may be a potential antitumor agent against ovarian cancer. |
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ISSN: | 1756-8919 1756-8927 |
DOI: | 10.4155/fmc-2022-0244 |