Transcriptomics of acute myeloid leukaemia core bone marrow biopsies reveals distinct therapy response‐specific osteo‐mesenchymal profiles

Summary While the bone marrow (BM) microenvironment is significantly remodelled in acute myeloid leukaemia (AML), molecular insight into AML‐specific alterations in the microenvironment has been historically limited by the analysis of liquid marrow aspirates rather than core biopsies that contain solid‐phase BM stroma. We assessed the effect of anthracycline‐ and cytarabine‐based induction chemotherapy on both haematopoietic and non‐haematopoietic cells directly in core BM biopsies using RNA‐seq and histological analysis. We compared matched human core BM biopsies at diagnosis and 2 weeks after cytarabine‐ and anthracycline‐based induction therapy in responders (