Progressive Acceleration of Insulin Exposure Over 7 Days of Infusion Set Wear

Progressive Acceleration of Insulin Exposure Over 7 Days of Infusion Set Wear

Insulin exposure varies over 3 days of insulin infusion set (IIS) wear making day-to-day insulin dosing challenging for people with diabetes (PWD). Here we report insulin pharmacodynamic (PD) and pharmacokinetic (PK) data extending these observations to 7 days of IIS wear. PWD (A1C ≤8.5%, C-peptide...

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Veröffentlicht in:Diabetes technology & therapeutics 2023-02, Vol.25 (2), p.143-147
Hauptverfasser: Kastner, Jasmin R, Bailey, Timothy S, Strange, Poul, Shi, Leon, Oberg, Keith A, Strasma, Paul J, Joseph, Jeffrey I, Muchmore, Douglas B
Format: Artikel
Sprache:eng
Schlagworte:
Blood Glucose
Brief Reports
Cross-Over Studies
Diabetes
Diabetes Mellitus
Diabetes Mellitus, Type 1 - drug therapy
Drug dosages
Glucose Clamp Technique
Humans
Hypoglycemic Agents
Infusion pumps
Insulin
Insulin Infusion Systems
Insulin Lispro
Insulin, Regular, Human - therapeutic use
Medical technology
Pharmacodynamics
Pharmacokinetics
Pilot Projects
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Zusammenfassung:Insulin exposure varies over 3 days of insulin infusion set (IIS) wear making day-to-day insulin dosing challenging for people with diabetes (PWD). Here we report insulin pharmacodynamic (PD) and pharmacokinetic (PK) data extending these observations to 7 days of IIS wear. PWD (A1C ≤8.5%, C-peptide
ISSN:1520-9156
1557-8593
DOI:10.1089/dia.2022.0323