Imidazole-pyridine hybrids as potent anti-cancer agents

In the current investigation, fifteen novel imidazole-pyridine-based molecules were synthesized and tested against cell lines of the lung (H1299) and colon (HCT116) adenocarcinomas by proliferation assay. The results demonstrated that compounds 5a, 5d, 5e, and 5f were the most active (IC50

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Bibliographische Detailangaben
Veröffentlicht in:	European journal of pharmaceutical sciences 2023-01, Vol.180, p.106323-106323, Article 106323
Hauptverfasser:	Aruchamy, Baladhandapani, Drago, Carmelo, Russo, Venera, Pitari, Giovanni Mario, Ramani, Prasanna, Aneesh, T P, Benny, Sonu, Vishnu, VR
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Carcinoma, Hepatocellular - drug therapy Glycogen Synthase Kinase 3 beta GSK-3β Hepatocellular carcinoma Humans Imidazole-pyridine scaffold Liver Neoplasms - drug therapy Molecular docking Molecular Docking Simulation One-pot synthesis Tumor cell proliferation
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Beschreibung
Zusammenfassung:	In the current investigation, fifteen novel imidazole-pyridine-based molecules were synthesized and tested against cell lines of the lung (H1299) and colon (HCT116) adenocarcinomas by proliferation assay. The results demonstrated that compounds 5a, 5d, 5e, and 5f were the most active (IC50
ISSN:	0928-0987 1879-0720
DOI:	10.1016/j.ejps.2022.106323