Vibrational Circular Dichroism Unravels Supramolecular Chirality and Hydration Polymorphism of Nucleoside Crystals

Invited for the cover of this issue are Valery Andrushchenko, Monika Krupová, and co‐workers at the Institute of Organic Chemistry and Biochemistry (IOCB Prague) of the Czech Academy of Sciences. The image depicts a “crystal city” illuminated by “chiral suns” shining left‐ and right‐circularly polarized light (L‐CPL and R‐CPL), which reveals differences in the structure of the chiral crystalline “skyscrapers”. Designed by Tomáš Belloň @ IOCB Prague. Read the full text of the article at 10.1002/chem.202201922. “VCD spectra of the same sample turned out to be of the opposite sign when the measurement was repeated, which was both enigmatic and fascinating!” This and more about the story behind the front cover can be found in the article at 10.1002/chem.202201922).