Preeclampsia, gestational hypertension and incident dementia: A systematic review and meta-analysis of published evidence

•The present systematic review and meta-analysis investigated the association between preeclampsia and future dementia.•Our results were indicative of an association between preeclampsia and incident vascular dementia.•Pooled findings revealed no association between preeclampsia and future Alzheimer’s disease or dementia of any type.•Gestational hypertension was not found to confer an elevated risk of incident dementia of any type. Novel data support a possible correlation between preeclampsia and congenital dysfunction. A systematic review of the literature and a meta-analysis was conducted according to the Preferred Reporting Items for Systematic Reviews and meta-Analyses (PRISMA) guidelines and the Cochrane Handbook for Systematic Reviews of Interventions. To investigate the association between the risk of future of dementia (vascular dementia, AD and dementia of any type) in women with a history of preeclampsia, based on current literature. Overall, three studies and 2.309.946 women were included in the present meta-analysis. There was no statistically significant association between history of preeclampsia or pregnancy hypertension disease and any type of dementia (p = 0.14 and p = 0.29, respectively). In contrast, there was a statistically significant difference between history of preeclampsia and vascular dementia (HR: 2.60; 95 %CI: 2.03–3.33; p