Adverse Events Associated With Treatment for Pan-Susceptible Tuberculosis in San Francisco

Adverse Events Associated With Treatment for Pan-Susceptible Tuberculosis in San Francisco

Abstract Of 373 patients treated for drug-susceptible tuberculosis, 35.4% (46.2% aged ≥65 years) developed moderate/severe adverse events that required treatment interruption (34.8%), first-line drug discontinuation (26.2%, primarily pyrazinamide), second-line drug initiation (30.0%), and treatment...

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Veröffentlicht in:Clinical infectious diseases 2023-03, Vol.76 (6), p.1121-1124
Hauptverfasser: Louie, Janice K, Keh, Chris, Agraz-Lara, Rocio, Phillips, Allison, Graves, Susannah
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Antitubercular Agents - adverse effects
Disease Susceptibility
Humans
San Francisco
Treatment Outcome
Tuberculosis - drug therapy
Tuberculosis, Multidrug-Resistant - drug therapy
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Zusammenfassung:Abstract Of 373 patients treated for drug-susceptible tuberculosis, 35.4% (46.2% aged ≥65 years) developed moderate/severe adverse events that required treatment interruption (34.8%), first-line drug discontinuation (26.2%, primarily pyrazinamide), second-line drug initiation (30.0%), and treatment duration up to 3.8 months longer. More safe and effective options are needed, including for the elderly.
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/ciac867