Outcome of elexacaftor/tezacaftor/ivacaftor therapy in patients with cystic fibrosis and solid organ transplantation

We report a case series of four patients with cystic fibrosis (CF) and previous solid organ transplantation (SOT) receiving elexacaftor/tezacaftor/ivacaftor therapy for 6 months or more. Data was collected retrospectively. The treatment was well tolerated and all patients reported subjective improve...

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Veröffentlicht in:	Pediatric pulmonology 2023-02, Vol.58 (2), p.602-605
Hauptverfasser:	Ørum, Matilde B., Rönsholt, Frederikke F., Jeppesen, Majbritt, Bendstrup, Elisabeth, Katzenstein, Terese L., Ott, Peter, Perch, Michael, Pressler, Tacjana, Qvist, Tavs, Jensen‐Fangel, Søren
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminophenols Benzodioxoles - adverse effects Case reports CFTR therapy Chloride Channel Agonists Cystic fibrosis Cystic Fibrosis - drug therapy Cystic Fibrosis - genetics Cystic Fibrosis Transmembrane Conductance Regulator - genetics Cystic Fibrosis Transmembrane Conductance Regulator - therapeutic use cystic fibrosis transmembrane conductance regulator therapy Double-Blind Method Drug Combinations Drug therapy ETI Humans Mutation Organ Transplantation Retrospective Studies solid organ transplantation Transplants & implants
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Zusammenfassung:	We report a case series of four patients with cystic fibrosis (CF) and previous solid organ transplantation (SOT) receiving elexacaftor/tezacaftor/ivacaftor therapy for 6 months or more. Data was collected retrospectively. The treatment was well tolerated and all patients reported subjective improvements.
ISSN:	8755-6863 1099-0496
DOI:	10.1002/ppul.26217