CircRNA_45478 promotes ischemic AKI by targeting the miR‐190a‐5p/PHLPP1 axis

A few studies suggested that circular RNAs were involved in the development of ischemic acute kidney injury (AKI). However, the function and regulation mechanism of circRNA_45478 in ischemic AKI remains unknown. In the present study, ischemic injury induced the expressions of circRNA_45478 in mouse proximal tubule‐derived cell lines (BUMPT cells) and kidneys of C57BL/6 mice. Functionally, circRNA_45478 mediated I/R‐induced apoptosis in BUMPT cells. Mechanistically, circRNA_45478 upregulated the expression of Pleckstrin homology (PH) domain leucine‐rich repeat protein phosphatase 1 (PHLPP1) via sponging of microRNA (miR)‐190a‐5p. Finally, inhibition of circRNA_45478 significantly alleviated the progression of ischemic AKI through regulation of the miR‐190a‐5p/PHLPP1 pathway. Taken together, our data showed that circRNA_45478/miR‐190a‐5p/PHLPP1 axis mediated the progression of ischemic AKI.