New indexes derived from routine blood tests and their clinical application in hepatocellular carcinoma

•The occurrence of HCC can cause a series of local and systemic changes, which can be reflected in routine clinical indicators.•New indexes derived from routine blood tests integrate several clinical indicators into a new single indicator that can reflect the patient's disease situation more comprehensively.•Conventional clinical indicators are daily medical data that are easy to collect and economic, repeat, so the creation of new indicators based on the conventional tests can be carried out at all levels of medical centers.•Current evidence supports the use of derived indicator for the risk prediction, clinical diagnosis and prognostic evaluation of hepatocellular carcinoma. Considerable efforts have been made in the diagnosis and treatment of hepatocellular carcinoma (HCC), but the prognosis of patients with HCC remains poor. The development of officious and easy-to-use indicators that are applicable to all levels of hospitals for the diagnosis, prognosis and risk prediction of HCC may play an important role in improving the current undesirable situation. The occurrence of HCC can cause a series of local and systemic changes, involving liver function, inflammation, immunity, and nutrition, which can be reflected in routine clinical indicators, especially laboratory metrics. A comprehensive analysis of these routine indicators is capable of providing important information for the clinical management of HCC. Routine clinical indicators are daily medical data that are readily available, easily repeatable, and highly acceptable, which has attracted clinicians to derive a number of comprehensive indexes from routine clinical indicators by means of four arithmetic operations, scoring system, and mathematical modeling. These indexes integrate several clinical indicators into a new single indicator that performs better than any of original individual indicators in the risk prediction, clinical diagnosis and prognostic evaluation of HCC and is easy to use. Herein, we reviewed recent indexes derived from routine clinical indicators for the diagnosis, prognosis and risk prediction of HCC.