Microbial carbonic anhydrase mediated carbon capture, sequestration & utilization: A sustainable approach to delivering bio-renewables

[Display omitted] •High hydration rate renders microbial CA as an attractive biomimetic route for carbon sequestration.•Recent advances through immobilization and protein engineering techniques enhancing CA applicability for post-combustion carbon capture.•Potential of CA-mediated carbon sequestration by phototrophs for biocatalytic conversion.•Enzymatic CO2 conversion & utilization applied to generate a multiproduct CO2 refinery. In the recent scenario, anthropogenic interventions have alarmingly disrupted climatic conditions. The persistent change in the climate necessitates carbon neutrality. Efficient ways of carbon capture and sequestration could be employed for sustainable product generation. Carbonic anhydrase (CA) is an enzyme that reversibly catalyzes the conversion of carbon dioxide to bicarbonate ions, further utilized by cells for metabolic processes. Hence, utilizing CA from microbial sources for carbon sequestration and the corresponding delivery of bio-renewables could be the eco-friendly approach. Consequently, the microbial CA and amine-based carbon capture chemicals are synergistically applied to enhance carbon capture efficiency and eventual utilization. This review comprehends recent developments coupled with engineering techniques, especially in microbial CA, to create integrated systems for CO2 sequestration. It envisages developing sustainable approaches towards mitigating environmental CO2 from industries and fossil fuels to generate bio-renewables and other value-added chemicals.