Tuning TPC2

Tuning TPC2

•Combined addition of TPC2-A1-N and TPC2-A1-P increases the permeability for Ca2+ions of two-pore channel 2 (TPC2).•TPC2 can be tuned to more rapid and larger Ca2+ signals by combined stimulation of TPC2 using TPC2-A1-N and TPC2-A1-P.•Mechanism of action of TPC2-A1-N needs clarification regarding cy...

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Veröffentlicht in:Cell calcium (Edinburgh) 2022-12, Vol.108, p.102653-102653, Article 102653
1. Verfasser: Guse, Andreas H.
Format: Artikel
Sprache:eng
Schlagworte:
Calcium - metabolism
Calcium Channels
Lysosomes - metabolism
NADP - metabolism
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Zusammenfassung:•Combined addition of TPC2-A1-N and TPC2-A1-P increases the permeability for Ca2+ions of two-pore channel 2 (TPC2).•TPC2 can be tuned to more rapid and larger Ca2+ signals by combined stimulation of TPC2 using TPC2-A1-N and TPC2-A1-P.•Mechanism of action of TPC2-A1-N needs clarification regarding cytosolic NAADP receptor proteins. [Display omitted]
ISSN:0143-4160
1532-1991
DOI:10.1016/j.ceca.2022.102653