Did circular DNA shape the evolution of mammalian genomes?

Did circular DNA shape the evolution of mammalian genomes?

Extrachromosomal circular DNA (eccDNA) can shape the genomes of somatic cells, but how it impacts genomes across generations is largely unexplored. We propose that genomes can rearrange via circular intermediates across generations and show that up to 6% of a mammalian genome can have changed gene o...

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Veröffentlicht in:Trends in biochemical sciences (Amsterdam. Regular ed.) 2023-04, Vol.48 (4), p.317-320
Hauptverfasser: Holt, Sylvester, Arrey, Gerard, Regenberg, Birgitte
Format: Artikel
Sprache:eng
Schlagworte:
Animals
deletion
DNA, Circular - genetics
eccDNA
evolution
mammal
Mammals - genetics
meiosis
synteny
transposition
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Zusammenfassung:Extrachromosomal circular DNA (eccDNA) can shape the genomes of somatic cells, but how it impacts genomes across generations is largely unexplored. We propose that genomes can rearrange via circular intermediates across generations and show that up to 6% of a mammalian genome can have changed gene order through eccDNA.
ISSN:0968-0004
1362-4326
DOI:10.1016/j.tibs.2022.09.010