Out of LINE: Transposons, genome integrity, and neurodegeneration

Out of LINE: Transposons, genome integrity, and neurodegeneration

Abnormal activity of LINE-1 transposable elements has been associated with neurological disease. In this issue of Neuron, Takahashi et al. (2022) show that L1 hyperactivity occurs in the neurodegenerative syndrome ataxia telangiectasia and causes ataxia and cerebellar degeneration in mice. Abnormal...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Neuron (Cambridge, Mass.) Mass.), 2022-10, Vol.110 (20), p.3217-3219
Hauptverfasser: Dumitrache, Lavinia C., McKinnon, Peter J.
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Abnormal activity of LINE-1 transposable elements has been associated with neurological disease. In this issue of Neuron, Takahashi et al. (2022) show that L1 hyperactivity occurs in the neurodegenerative syndrome ataxia telangiectasia and causes ataxia and cerebellar degeneration in mice. Abnormal activity of LINE-1 transposable elements has been associated with neurological disease. In this issue of Neuron, Takahashi et al. (2022) show that L1 hyperactivity occurs in the neurodegenerative syndrome ataxia telangiectasia and causes ataxia and cerebellar degeneration in mice.
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2022.09.026