Clinical Reasoning: A 39-Year-Old Man With Asymmetric Distal Weakness and Loss of Sensitivity

A 39-year-old man presented with an asymmetric distal weakness and loss of sensitivity sequentially affecting both lower extremities and the left upper limb. Nerve conduction studies showed a multifocal sensory and motor axonal neuropathy, and a pseudo-conduction block of the right fibular nerve, th...

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Veröffentlicht in:Neurology 2023-01, Vol.100 (2), p.88-93
Hauptverfasser: Loser, Valentin, Blanchard, Gabriela, Guenova, Emmanuella, Théaudin, Marie, Vicino, Alex
Format: Artikel
Sprache:eng
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Zusammenfassung:A 39-year-old man presented with an asymmetric distal weakness and loss of sensitivity sequentially affecting both lower extremities and the left upper limb. Nerve conduction studies showed a multifocal sensory and motor axonal neuropathy, and a pseudo-conduction block of the right fibular nerve, the whole being consistent with a mononeuropathy multiplex. An uncommon etiology was found after an extensive workup. Axonal loss was severe, with only partial response to treatment with corticosteroids and IV immunoglobulins.
ISSN:0028-3878
1526-632X
DOI:10.1212/WNL.0000000000201410