Pathways to depression: Dynamic associations between neural responses to appetitive cues in the environment, stress, and the development of illness

This review focuses on research my colleagues and I have conducted on etiological pathways to depression. Much of this work has focused on the measurement of neural responses to appetitive cues, using two event‐related brain potential (ERP) components, the Late Positive Potential (LPP) and the Reward Positivity (RewP). Reductions in each of these components have been associated with current symptoms of depression, and in some cases have been shown to differentiate anxious from depressive phenotypes. In this review, I will describe three broad and related approaches we have taken in our research to address a series of interdependent issuess. The first attempts to understand different sources of variation in the LPP and RewP, and how these sources interact with one another. The second tries to identify whether variation in the processes measured by these ERP components might reflect a latent vulnerability to depression and its symptoms, that is evident prior to illness onset. And the third examines the possibility that the processes reflected in the LPP and RewP might play a mechanistic role in the development of depression. This review summarizes research my colleagues and I have undertaken to understand the role neural responses to appetitive cues play in pathways to depression. I describe our work attempting to identify sources of variation in these neural responses and to understand how variation in these neural responses interacts with exposure to stressful life events to contribute to the emergence of depressive symptoms and disorders.