The Evaluation of Transmural Healing by Low-dose Computed Tomography Enterography in Patients with Crohn's Disease

Objective Transmural healing (TH) has been attracting attention as a new therapeutic target for Crohn's disease, but there are few clinical data on TH in Japan. We introduced low-dose computed tomography enterography (CTE) as a monitoring method for Crohn's disease and retrospectively inve...

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Veröffentlicht in:Internal Medicine 2022/10/15, Vol.61(20), pp.2999-3007
Hauptverfasser: Fujimura, Hiroyuki, Hashimoto, Shinichi, Shimizu, Kensaku, Onoda, Hideko, Tanabe, Masahiro, Higashi, Mayumi, Ogawa, Ryo, Goto, Atsushi, Hamabe, Koichi, Nishikawa, Jun, Ito, Katsuyoshi, Takami, Taro
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Sprache:eng
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Zusammenfassung:Objective Transmural healing (TH) has been attracting attention as a new therapeutic target for Crohn's disease, but there are few clinical data on TH in Japan. We introduced low-dose computed tomography enterography (CTE) as a monitoring method for Crohn's disease and retrospectively investigated the accuracy of evaluating TH by CTE. Methods Among Crohn's disease patients who underwent low-dose CTE at our hospital from January 2009 to March 2021, 122 patients who underwent colonoscopy or balloon endoscopy within 2 weeks were included. Results of radiological and endoscopic examinations were reviewed independently by radiologists and gastrointestinal endoscopists, respectively. The concordance rate of the diagnosis between CTE and endoscopy was evaluated. Results Twenty-six patients (21.3%) achieved TH, and the kappa index was 0.743. On comparing the TH and non-TH groups, the Crohn's disease activity index (p=0.02), endoscopic healing rate (p
ISSN:0918-2918
1349-7235
1349-7235
DOI:10.2169/internalmedicine.9066-21