Preventive effects of preoperative ramelteon on postoperative delirium in Asian elderly population: A randomized, double-blind, placebo-controlled trial, and a systematic review and meta-analysis

•RCT was performed to test whether low-dose ramelteon reduces postoperative delirium.•We ran Asian meta-analysis of RCTs for ramelteon effects on postoperative delirium.•The meta-analysis showed ramelteon reduced postoperative delirium in Asian elderly.

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Bibliographische Detailangaben
Veröffentlicht in:	Asian journal of psychiatry 2022-12, Vol.78, p.103282-103282, Article 103282
Hauptverfasser:	Tanifuji, Takaki, Otsuka, Ikuo, Okazaki, Satoshi, Horai, Tadasu, So, Ryuhei, Shiroiwa, Kyoichi, Mouri, Kentaro, Tanaka, Motofumi, Ohmoto, Nobuko, Sora, Ichiro, Hirai, Midori, Fukumoto, Takumi, Ku, Yonson, Hishimoto, Akitoyo
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Asian population Delirium - prevention & control Double-Blind Method Humans Indenes - therapeutic use Melatonin Meta-analysis Postoperative delirium Randomized controlled trial Randomized Controlled Trials as Topic
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Beschreibung
Zusammenfassung:	•RCT was performed to test whether low-dose ramelteon reduces postoperative delirium.•We ran Asian meta-analysis of RCTs for ramelteon effects on postoperative delirium.•The meta-analysis showed ramelteon reduced postoperative delirium in Asian elderly.
ISSN:	1876-2018 1876-2026
DOI:	10.1016/j.ajp.2022.103282