When NOD ligands become antidotes

When NOD ligands become antidotes

Loss-of-function mutations in NOD2, a receptor-sensing microbiota-derived muropeptides, is a genetic predisposition for Crohn's disease (CD). In this issue of Cell Host & Microbe, Gao et al. (2022) identify a microbiota-derived peptidoglycan remodeling enzyme that dampens chronic intestinal...

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Veröffentlicht in:Cell host & microbe 2022-10, Vol.30 (10), p.1345-1346
1. Verfasser: Chassaing, Benoit
Format: Artikel
Sprache:eng
Schlagworte:
Antidotes
Crohn Disease
Genetic Predisposition to Disease
Humans
Inflammation
Ligands
Mutation
Nod2 Signaling Adaptor Protein - genetics
Peptidoglycan
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Zusammenfassung:Loss-of-function mutations in NOD2, a receptor-sensing microbiota-derived muropeptides, is a genetic predisposition for Crohn's disease (CD). In this issue of Cell Host & Microbe, Gao et al. (2022) identify a microbiota-derived peptidoglycan remodeling enzyme that dampens chronic intestinal inflammation via NOD2, offering a potential path to alleviate CD.
ISSN:1931-3128
1934-6069
DOI:10.1016/j.chom.2022.09.009