A pH-responsive cascade nanoplatform with circulating oxygen supply for collaborative breast cancer treatment

A pH-responsive cascade nanoplatform with circulating oxygen supply for collaborative breast cancer treatment

A pH-responsive cascade nanoplatform based on ZIF-8 disintegrates in the weakly acidic tumor microenvironment to release MnO 2 , CaO 2 and Ce6. The drugs can cyclically generate O 2 for sonodynamic therapy, consume glutathione to tune the redox hemostasis, and produce cytotoxic &z.rad;OH to kill...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2022-10, Vol.58 (86), p.129-1293
Hauptverfasser: Gao, Xiaonan, Jia, Zhikai, Cheng, Yaoying, Ouyang, Mingyi, Feng, Lin, Wang, Yuzhuo, Tang, Bo, Xu, Kehua
Format: Artikel
Sprache:eng
Schlagworte:
Disintegration
Glutathione
Hemostatics
Manganese dioxide
Tumors
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Zusammenfassung:A pH-responsive cascade nanoplatform based on ZIF-8 disintegrates in the weakly acidic tumor microenvironment to release MnO 2 , CaO 2 and Ce6. The drugs can cyclically generate O 2 for sonodynamic therapy, consume glutathione to tune the redox hemostasis, and produce cytotoxic &z.rad;OH to kill tumor cells via chemical dynamics therapy. A pH-responsive cascade nanoplatform based on ZIF-8 disintegrates in the weakly acidic tumor microenvironment to release MnO 2 , CaO 2 and Ce6.
ISSN:1359-7345
1364-548X
DOI:10.1039/d2cc02044k