A gut feeling

Unbiased metabolomics revealed the conversion of serotonin into N -acetylserotonin-derived glucosides by an intestinal carboxylesterase in Caenorhabditis elegans , which suggests an unappreciated role of the gut in modulating 5-HT signaling.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature chemical biology 2023-02, Vol.19 (2), p.125-126
1. Verfasser:	Sze, Ji Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/136/334/1582/712 631/378/340 631/92/1643 631/92/320 Biochemical Engineering Biochemistry Biology Bioorganic Chemistry Biosynthesis Carboxylesterase Cell Biology Chemistry Chemistry and Materials Science Chemistry/Food Science Digestive system Gastrointestinal tract Glucosides Metabolism Metabolites Metabolomics Microbiota N-Acetylserotonin News & Views news-and-views Physiology Serotonin
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Beschreibung
Zusammenfassung:	Unbiased metabolomics revealed the conversion of serotonin into N -acetylserotonin-derived glucosides by an intestinal carboxylesterase in Caenorhabditis elegans , which suggests an unappreciated role of the gut in modulating 5-HT signaling.
ISSN:	1552-4450 1552-4469
DOI:	10.1038/s41589-022-01152-x