Evaluation of the Content of Aquaporin-5 and Epithelial Sodium Channel in the Lungs of Rats during the Development of Toxic Pulmonary Edema Caused by Intoxication with Acylating Pulmonotoxicants

Evaluation of the Content of Aquaporin-5 and Epithelial Sodium Channel in the Lungs of Rats during the Development of Toxic Pulmonary Edema Caused by Intoxication with Acylating Pulmonotoxicants

We studied the content of aquaporin-5 (AQP 5 ) and epithelial sodium channel (ENaC) in rat lungs during the development of toxic pulmonary edema (TPE) caused by intoxication with phosgene and perfluoroisobutylene (1.5 LC 50 ). The lung body weight index (LBI) was calculated and histological examinat...

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Veröffentlicht in:Bulletin of experimental biology and medicine 2022-09, Vol.173 (5), p.623-627
Hauptverfasser: Tolkach, P. G., Basharin, V. A., Chepur, S. V., Sizova, D. T., Vengerovich, N. G., Yudin, M. A., Nikiforov, A. S., Chaykina, M. A.
Format: Artikel
Sprache:eng
Schlagworte:
Alveoli
Aquaporin 5
Aquaporins
Biomedical and Life Sciences
Biomedicine
Body weight
Cell Biology
Edema
Immunohistochemistry
Internal Medicine
Intoxication
Laboratory Medicine
Localization
Lungs
Pathology
Phosgene
Pulmonary edema
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Zusammenfassung:We studied the content of aquaporin-5 (AQP 5 ) and epithelial sodium channel (ENaC) in rat lungs during the development of toxic pulmonary edema (TPE) caused by intoxication with phosgene and perfluoroisobutylene (1.5 LC 50 ). The lung body weight index (LBI) was calculated and histological examination of the lung tissues was performed. Localization and expression of AQP 5 and ENaC were determined by immunohistochemistry. Intoxication led to a significant ( p
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-022-05600-5