Colon cancer and colorectal cancer: Prevention and treatment by potential natural products
Colon cancer affects both men and women and is the world's second most significant cause of cancer-related mortality. Colon cancer death rates have risen worldwide due to the current food habit and lifestyle, which include a lot of meat, alcohol, and not enough physical exercise. As a result, n...
Gespeichert in:
Veröffentlicht in: | Chemico-biological interactions 2022-12, Vol.368, p.110170-110170, Article 110170 |
---|---|
Hauptverfasser: | , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | Colon cancer affects both men and women and is the world's second most significant cause of cancer-related mortality. Colon cancer death rates have risen worldwide due to the current food habit and lifestyle, which include a lot of meat, alcohol, and not enough physical exercise. As a result, novel, less harmful pharmacological treatments for colon cancer are needed now more than ever before. Colorectal cancer (CRC) affects a significant portion of the world's population. Chemotherapy's limits, as demonstrated by side effects and resistance in CRC patients, are now being sought after despite recent breakthroughs that have improved patient care and survival. Numerous chemical compounds present in medicinal herbs have shown anti-tumor and anti-apoptotic properties against various cancers, including CRC, in animal experiments. These chemicals, which come from several phytochemical families, activate several signaling pathways. This article discusses research on the anti-CRC benefits of many plants conducted in vitro, as well as the phytochemical components of plants that may play a role in the study. Researchers are also looking into the impact of these compounds on various pathways involved in cancer signaling. According to this review, anti-CRC compounds may be generated from medicinal plants. That's why we're looking at how natural items can help treat cancer while lowering the risk of developing it.
•Tumor cell proliferation may be inhibited and apoptosis can be induced by medicinal plants.•There are ways in which plants and their key ingredients impact the transcription and cell cycle.•Chemicals from plants enhance levels of a variety of proteins and cell cycle inhibitors.•Progression of colon cancer cells and its ability to multiply may be stopped by medicinal herbs.•In vivo research has to be conducted on the chemicals before they are used for therapeutics. |
---|---|
ISSN: | 0009-2797 1872-7786 |
DOI: | 10.1016/j.cbi.2022.110170 |