Lower tacrolimus time in therapeutic range is associated with inferior outcomes in adult liver transplant recipients

Previous studies on solid organ transplantation have reported that a low time in therapeutic range (TTR) of tacrolimus increases the risk of poor outcomes. However, the reproducibility of the findings in liver transplantation has not yet been confirmed. The TTR, coefficient of variation (CV) and standard deviation (SD) were calculated for 207 adult liver transplant patients from the date of transplantation until the first episode of acute rejection (AR), graft loss, acute kidney injury (AKI), biliary complications, infection or the last follow‐up. Kaplan–Meier curves, log‐rank tests and Cox regression analyses were performed. Sixty‐one (29.5%) patients reached the composite endpoint of AR, biliary complications and graft loss. The log‐rank test indicated that the low TTR group had an increased risk of the composite endpoint (P