Site-specific unnatural base excision via visible light

Site-specific unnatural base excision via visible light

Base excision (BE) is an important yet hard-to-control biological event. Unnatural base pairs are powerful tools to revolutionize biological studies in various areas. In this paper, we report a visible-light-induced method to construct site-specific unnatural BE and show the influence of its regulat...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2022-10, Vol.58 (83), p.11717-11720
Hauptverfasser: Guo, Yuan-Yang, Zhang, Rujie, Huo, Bianbian, Wang, Luying, Yuan, Donghe, Bai, Jingsi, Wang, Honglei, Zhu, Gongming, Zhang, Xiguang, Zhu, Anlian, Chen, Tingjian, Li, Lingjun
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Sprache:eng
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Zusammenfassung:Base excision (BE) is an important yet hard-to-control biological event. Unnatural base pairs are powerful tools to revolutionize biological studies in various areas. In this paper, we report a visible-light-induced method to construct site-specific unnatural BE and show the influence of its regulation on transcription and translation levels.
ISSN:1359-7345
1364-548X
DOI:10.1039/d2cc03664a