EF24, a schistosomicidal curcumin analog: Insights from its synthesis and phenotypic, biochemical and cytotoxic activities

EF24, a schistosomicidal curcumin analog: Insights from its synthesis and phenotypic, biochemical and cytotoxic activities

Praziquantel (PZQ) is the only drug available for community-based control programs which aim to reduce the prevalence and morbidity associated with schistosomiasis. Here, we synthesized and evaluated the schistosomicidal, biochemical and cytotoxic activities of EF24, a synthetic curcumin analog, aga...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemico-biological interactions 2022-12, Vol.368, p.110191-110191, Article 110191
Hauptverfasser: Badoco, Fernanda R., Paula, Lucas A.L., Orenha, Renato P., Mendes, Tiago M.F., Squarisi, Iara S., El-Sakkary, Nelly, Loiola, Messias C., Katz, Naftale, Tavares, Denise C., Sairre, Mirela I., Parreira, Renato Luis T., Janku Cabral, Fernanda, Alegretti, Silmara M., Caffrey, Conor R., Magalhães, Lizandra G.
Format: Artikel
Sprache:eng
Schlagworte:
Curcumin analog
EF24
Schistosoma mansoni isolates
Schistosomicidal
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Praziquantel (PZQ) is the only drug available for community-based control programs which aim to reduce the prevalence and morbidity associated with schistosomiasis. Here, we synthesized and evaluated the schistosomicidal, biochemical and cytotoxic activities of EF24, a synthetic curcumin analog, against different isolates of Schistosoma mansoni. EF24 elicited marked phenotypic alterations at 10 μM against schistosomula and 42-day-old adult worms of the Naval Medical Research Institute (NMRI) isolate. EF24 had 50% effective concentration (EC50) values of
ISSN:0009-2797
1872-7786
DOI:10.1016/j.cbi.2022.110191