A nomenclature consensus for nervous system organoids and assembloids

Self-organizing three-dimensional cellular models derived from human pluripotent stem cells or primary tissue have great potential to provide insights into how the human nervous system develops, what makes it unique and how disorders of the nervous system arise, progress and could be treated. Here,...

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Veröffentlicht in:Nature (London) 2022-09, Vol.609 (7929), p.907-910
Hauptverfasser: Pașca, Sergiu P., Arlotta, Paola, Bateup, Helen S., Camp, J. Gray, Cappello, Silvia, Gage, Fred H., Knoblich, Jürgen A., Kriegstein, Arnold R., Lancaster, Madeline A., Ming, Guo-Li, Muotri, Alysson R., Park, In-Hyun, Reiner, Orly, Song, Hongjun, Studer, Lorenz, Temple, Sally, Testa, Giuseppe, Treutlein, Barbara, Vaccarino, Flora M.
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Sprache:eng
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Zusammenfassung:Self-organizing three-dimensional cellular models derived from human pluripotent stem cells or primary tissue have great potential to provide insights into how the human nervous system develops, what makes it unique and how disorders of the nervous system arise, progress and could be treated. Here, to facilitate progress and improve communication with the scientific community and the public, we clarify and provide a basic framework for the nomenclature of human multicellular models of nervous system development and disease, including organoids, assembloids and transplants. The nomenclature for human multicellular models of nervous system development and disease, including organoids, assembloids and transplants, is discussed and a consensus framework is presented.
ISSN:0028-0836
1476-4687
1476-4687
DOI:10.1038/s41586-022-05219-6