Palladium-Catalyzed Borylative Cyclizations of α‑(2-Bromoaryl) Ketones to Form 1,2-Benzoxaborinines

Palladium-Catalyzed Borylative Cyclizations of α‑(2-Bromoaryl) Ketones to Form 1,2-Benzoxaborinines

Herein, we report that palladium catalyzes the borylative cyclization of α-(2-bromoaryl) ketones to afford 1,2-benzoxa­borinines. The developed system is compatible with a variety of functionalities (Me, t-Bu, OMe, NMe2, F, Cl, CN, CF3, CO2Me, and heteroaryl groups) and is applicable to the synthesi...

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Veröffentlicht in:Organic letters 2022-10, Vol.24 (39), p.7227-7231
Hauptverfasser: Shigeno, Masanori, Iseya, Yuto, Kume, Ryotaro, Nozawa-Kumada, Kanako, Kondo, Yoshinori
Format: Artikel
Sprache:eng
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Zusammenfassung:Herein, we report that palladium catalyzes the borylative cyclization of α-(2-bromoaryl) ketones to afford 1,2-benzoxa­borinines. The developed system is compatible with a variety of functionalities (Me, t-Bu, OMe, NMe2, F, Cl, CN, CF3, CO2Me, and heteroaryl groups) and is applicable to the synthesis of B–O-containing tri- and tetracyclic fused-ring compounds.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.2c03033