Soft detoxification of chemical warfare agent simulants and pesticides under pressure

The neutralisation of structurally varied chemical warfare agent simulants (blister and nerve agents) and pesticides (Paraoxon) with the assistance of high pressure is reported. Chloroethyl amines and sulfides (nitrogen and sulfur mustards), phosphonothioates (V-series nerve agents) and phosphates (pesticide) readily react with simple nucleophilic scavengers (alcohols, amines) at P > 14 000 bar. The combination of very high pressure and simple nucleophilic scavengers (alcohols, amines) promotes the detoxification of nitrogen and sulfur mustards, V-series nerve agents and pesticides.