Copper-Catalyzed Regio- and Stereoselective Sulfonylation of Alkynyl Imines with Sulfonyl Hydrazides: Access to (E)‑β-Sulfonyl Enones

Copper-Catalyzed Regio- and Stereoselective Sulfonylation of Alkynyl Imines with Sulfonyl Hydrazides: Access to (E)‑β-Sulfonyl Enones

A copper-catalyzed sulfonylation of alkynyl imines with sulfonyl hydrazides has been developed, which exhibited excellent regio- and stereoselectivity and furnished a series of (E)-β-sulfonyl enones in moderate to good yields. Mechanistic studies suggest that this strategy goes through a radical pro...

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Veröffentlicht in:Journal of organic chemistry 2022-10, Vol.87 (19), p.13322-13330
Hauptverfasser: Chen, Rongxiang, Li, Shaozhu, Zhang, Jinju, Cao, Jing, Wang, Kai-Kai, Meng, Tuanjie, Liu, Lantao
Format: Artikel
Sprache:eng
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Zusammenfassung:A copper-catalyzed sulfonylation of alkynyl imines with sulfonyl hydrazides has been developed, which exhibited excellent regio- and stereoselectivity and furnished a series of (E)-β-sulfonyl enones in moderate to good yields. Mechanistic studies suggest that this strategy goes through a radical process.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.2c01192