Liver graft injury caused by de novo donor-specific HLA antibodies in pediatric liver transplant recipients with low, moderate, and high immunologic risk

This study investigated the association between different risk levels of de novo donor-specific anti-human leukocyte antigen antibodies (dnDSAs) and liver graft injury after liver transplantation in pediatric patients. This retrospective cohort study enrolled 130 patients after liver transplantation...

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Veröffentlicht in:	The American journal of surgery 2023-02, Vol.225 (2), p.275-281
Hauptverfasser:	Liu, Wei, Wang, Zheng-Lu, Kang, Zhong-Yu, Xiao, Yan-Li, Liu, Chun, Li, Dai-Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antigens Bilirubin Biopsy Child De novo donor-specific anti-HLA antibodies Fibrosis Fluorescence Graft rejection Graft Rejection - etiology Graft Survival Grafting Health risks Histocompatibility antigen HLA Humans Injuries Kidney Transplantation Leukocytes Liver Liver Cirrhosis Liver graft injury Liver Transplantation Liver transplants Lymphocytes Lymphocytes T Patients Pediatric liver transplantation Pediatrics Rejection Retrospective Studies Risk Factors Risk groups Risk levels Software Statistical analysis Survival Tissue Donors Transplant Recipients Transplantation
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Beschreibung
Zusammenfassung:	This study investigated the association between different risk levels of de novo donor-specific anti-human leukocyte antigen antibodies (dnDSAs) and liver graft injury after liver transplantation in pediatric patients. This retrospective cohort study enrolled 130 patients after liver transplantation. Subjects were divided into the following 4 groups according to the mean fluorescence intensity (MFI) of dnDSAs: high risk group(MFI ≥10,000), medium risk group(4000 ≤ MFI
ISSN:	0002-9610 1879-1883
DOI:	10.1016/j.amjsurg.2022.09.007