Slow Waning of Antibodies Following BNT162b2 as a Third Dose in Adults Who Had Previously Received 2 Doses of Inactivated Vaccine

Slow Waning of Antibodies Following BNT162b2 as a Third Dose in Adults Who Had Previously Received 2 Doses of Inactivated Vaccine

Abstract We administered BNT162b2 as a third dose to 314 adults aged ≥30 years who had previously received 2 doses of inactivated vaccine. We collected blood samples before the third dose and again after 1 month and 6 months, and found robust antibody responses to the ancestral strain at 6 months af...

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Veröffentlicht in:The Journal of infectious diseases 2023-01, Vol.227 (2), p.251-255
Hauptverfasser: Cowling, Benjamin J, Cheng, Samuel M S, Martín-Sánchez, Mario, Au, Niki Y M, Chan, Karl C K, Li, John K C, Fung, Lison W C, Luk, Leo L H, Tsang, Leo C H, Ip, Dennis K M, Poon, Leo L M, Leung, Gabriel M, Peiris, J S Malik, Leung, Nancy H L
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Antibodies
Antibodies, Viral
BNT162 Vaccine
Humans
Vaccines, Inactivated
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Zusammenfassung:Abstract We administered BNT162b2 as a third dose to 314 adults aged ≥30 years who had previously received 2 doses of inactivated vaccine. We collected blood samples before the third dose and again after 1 month and 6 months, and found robust antibody responses to the ancestral strain at 6 months after receipt of BNT162b2. Antibody responses to Omicron BA.2 by live virus neutralization were weaker after the third dose and had declined to a low level by 6 months.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jiac380