Powder cohesion and energy to break an avalanche: Can we address surface heterogeneity?

Powder cohesion and energy to break an avalanche: Can we address surface heterogeneity?

[Display omitted] •The cohesion was related to the specific surface area.•The dispersive component of the surface energy (van der Waals forces) prevailed.•Surface heterogeneity results confirmed preferable drug-excipient interactions.•Alginic acid showed a better carrier effect than calcium alginate...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:International journal of pharmaceutics 2022-10, Vol.626, p.122198-122198, Article 122198
Hauptverfasser: Brokešová, Jana, Niederquell, Andreas, Kuentz, Martin, Zámostný, Petr, Vraníková, Barbora, Šklubalová, Zdenka
Format: Artikel
Sprache:eng
Schlagworte:
Avalanches
Particle Size
Powders
Technology, Pharmaceutical
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:[Display omitted] •The cohesion was related to the specific surface area.•The dispersive component of the surface energy (van der Waals forces) prevailed.•Surface heterogeneity results confirmed preferable drug-excipient interactions.•Alginic acid showed a better carrier effect than calcium alginate.•The Wadh/Wcoh ratio near to unity confirmed stability of interactive mixtures.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2022.122198