Novel technique for rosacea treatment using optimal pulse technology: In vivo and clinical studies

Background Rosacea is a chronic inflammatory skin disease affecting the face, and the current treatment effect is not satisfactory. Based on the photomodulation of optimal pulse technology (OPT), we developed a novel treatment mode, namely, advanced OPT with low energy, three pulses, and long pulse width (AOPT‐LTL). Aims We aimed to explore the feasibility and underlying molecular mechanisms of AOPT‐LTL treatment in a rosacea‐like mouse model. Furthermore, we evaluated the safety and efficacy in patients with erythematotelangiectatic rosacea (ETR). Materials and methods Morphological, histological, and immunohistochemical analyses were used to investigate the efficacy and mechanisms of AOPT‐LTL treatment in the LL‐37‐induced rosacea‐like mouse model. Moreover, 23 patients with ETR were included and received different times of treatment at intervals of 2 weeks depending on the severity of their condition. The treatment effect was assessed by comparing clinical photographs at baseline, 1 week, and 3 months after treatment, combined with the red value, GFSS, and CEA scores. Results After the AOPT‐LTL treatment of the mice, we observed that the rosacea‐like phenotype, inflammatory cell infiltration, and vascular abnormalities were significantly ameliorated, and the expression of the core molecules of rosacea was significantly inhibited. In the clinical study, the AOPT‐LTL treatment exerted satisfactory therapeutic effects on erythema and flushing of ETR patients. No serious adverse events were observed. Conclusions AOPT‐LTL is a safe and effective method for the treatment of ETR.