Azanza garckeana ameliorates Bisphenol A-induced reproductive toxicities in rabbit bucks
This study evaluated the ameliorative properties of Azanza garckeana in Bisphenol A-induced reproductive toxicities on weight, spermiogram, serum hormonal profile, sperm DNA integrity, histopathology of testes and brain tissues of rabbit bucks. Twenty-eight rabbit bucks, with live weight of 1.20–2.0...
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Veröffentlicht in: | Theriogenology 2022-10, Vol.192, p.150-165 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | This study evaluated the ameliorative properties of Azanza garckeana in Bisphenol A-induced reproductive toxicities on weight, spermiogram, serum hormonal profile, sperm DNA integrity, histopathology of testes and brain tissues of rabbit bucks. Twenty-eight rabbit bucks, with live weight of 1.20–2.00 kg and aged 10–18 months. They were randomly divided into four groups of seven bucks each, group A was administered distilled water (1.5 mL) daily for 12 weeks, group B was administered Bisphenol A (100 mg/kg) for 5 consecutive days in a week for a period of 12 weeks, group C was administered Azanza garckeana (500 mg/kg) daily for 12 weeks and group D was pre-dosed with Bisphenol A (100 mg/kg) for 5 consecutive days in a week over 6 weeks period followed by Azanza garckeana (500 mg/kg) daily for another 6 weeks. Mean testicular weights differed significantly (p |
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ISSN: | 0093-691X 1879-3231 |
DOI: | 10.1016/j.theriogenology.2022.08.023 |