Azanza garckeana ameliorates Bisphenol A-induced reproductive toxicities in rabbit bucks

This study evaluated the ameliorative properties of Azanza garckeana in Bisphenol A-induced reproductive toxicities on weight, spermiogram, serum hormonal profile, sperm DNA integrity, histopathology of testes and brain tissues of rabbit bucks. Twenty-eight rabbit bucks, with live weight of 1.20–2.0...

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Veröffentlicht in:Theriogenology 2022-10, Vol.192, p.150-165
Hauptverfasser: Itodo, Joy Iyojo, Rekwot, Peter Ibrahim, Aluwong, Tagang, Allam, Lushaikyaa, Jolayemi Olutimilehin, Kelvin, Kyari, Stephen, Abah, Kenneth Owoicho, Ibrahim, Shettima, Dogara, Mohammed Umar, Yusuf Abdulrafiu, Tayo, Makama, Musa Mohammed, Mundi, Harirat Ladi, Abdullahi, Hudu Ramalan
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Sprache:eng
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Zusammenfassung:This study evaluated the ameliorative properties of Azanza garckeana in Bisphenol A-induced reproductive toxicities on weight, spermiogram, serum hormonal profile, sperm DNA integrity, histopathology of testes and brain tissues of rabbit bucks. Twenty-eight rabbit bucks, with live weight of 1.20–2.00 kg and aged 10–18 months. They were randomly divided into four groups of seven bucks each, group A was administered distilled water (1.5 mL) daily for 12 weeks, group B was administered Bisphenol A (100 mg/kg) for 5 consecutive days in a week for a period of 12 weeks, group C was administered Azanza garckeana (500 mg/kg) daily for 12 weeks and group D was pre-dosed with Bisphenol A (100 mg/kg) for 5 consecutive days in a week over 6 weeks period followed by Azanza garckeana (500 mg/kg) daily for another 6 weeks. Mean testicular weights differed significantly (p 
ISSN:0093-691X
1879-3231
DOI:10.1016/j.theriogenology.2022.08.023