The expression of miR‐181b, CYLD, CBX‐7, BCL2, and p53 in osteosarcoma patients and correlation with clinicopathological factors

Osteosarcoma is a common human malignancy with a high mortality rate worldwide. Recent studies have been focused on understanding the involvement of microRNA (miRNAs) in the pathogenesis of osteosarcoma. Therefore, the present study aimed to measure the expression levels of miR‐181a, cylindromatosis...

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Veröffentlicht in:Chemical biology & drug design 2023-01, Vol.101 (1), p.2-8
Hauptverfasser: Fazli, Jafar, Fattah, Khashayar, Moliani, Afshin, Valizadeh, Amir, Bazavar, Mohammadreza
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Sprache:eng
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Zusammenfassung:Osteosarcoma is a common human malignancy with a high mortality rate worldwide. Recent studies have been focused on understanding the involvement of microRNA (miRNAs) in the pathogenesis of osteosarcoma. Therefore, the present study aimed to measure the expression levels of miR‐181a, cylindromatosis (CYLD), chromo box homolog 7 (CBX7), B‐cell lymphoma 2 (BCL2), and tumor protein p53 in tumor tissue and adjacent normal tissues in patients with osteosarcoma and its relationship with clinicopathological factors. The expression levels of miR‐181a, CYLD, CBX7, BCL2, and p53 were measured in 60 patients with osteosarcoma using quantitative real‐time polymerase chain reaction. Finally, we compared the relationship between these gene levels and clinicopathological factors in tumor and healthy tissues. Our results showed that the expression levels of miR‐181a, BCL2, and p53 were significantly higher in osteosarcoma tissue in comparison with normal tissues (p 
ISSN:1747-0277
1747-0285
DOI:10.1111/cbdd.14144