Modulatory role of Bovine serum albumin conjugated manganese dioxide nanoparticle on microwave radiation induced alterations in reproductive parameters of rat

In recent decades, microwave (MW) radiations are being used extensively for various applications such as Wi-Fi, telecommunication, etc. due to which there have been grave concerns regarding the adverse effects of MW exposure on human health, particularly the reproductive system. MW cause damage to the reproductive system by generating free radicals, decreasing antioxidant defence, and inducing oxidative stress. Hence, the present study was aimed to counteract the harmful effect by using antioxidant enzymes mimicking nanoparticle, Bovine serum albumin (BSA) conjugated manganese dioxide nanoparticle (MNP*). Male Wistar rats were exposed to MW and treated with MNP*, and their individual, as well as combined effect on reproductive parameters was investigated. Results showed that MW exposed rats had significantly reduced testosterone levels along with alterations in the testicular morphology. The antioxidant status decreased, and lipid peroxidation increased significantly in testis. MW exposure also showed altered sperm parameters such as a significant decrease in sperm count, viability, membrane integrity and mitochondrial activity with a significant increase in morphological abnormality and lipid peroxidation. As a result, the changes induced by MW may affect male fertility. However, upon combined exposure of MNP* and MW, these alterations were reduced significantly. Hence, it may be concluded that MNP* could reduce oxidative stress mediated damages in the reproductive system of rats owing to its antioxidant activity, and thus have a potential to act as a radioprotectant. •Microwave (MW) radiations have harmful effect on male reproductive system.•MW exposed rats showed significant alterations in male reproductive parameters.•BSA-Manganese dioxide nanoparticle (MNP*) mimic multiple antioxidant enzymes.•Rats were co-treated with MW and MNP*.•The co-treatment ameliorated the adverse effects induced by MW radiations.