Biological role of long non-coding RNA FTX in cancer progression

Long non-coding RNAs (LncRNAs) are involved in several types of cancer and participate actively in tumorigenesis and disease progression. LncRNA FTX is the transcription product of the FTX gene located at the X-inactivation center (Xic). LncRNA FTX has been shown to regulate cancer cell proliferation, migration, and aberrant metabolism, as well as increase tumor growth and metastasis in vivo. Herein, we summarized currently available research on the interaction between LncRNA FTX and associated molecules and signaling pathways in malignant tumors to better understand the biological roles of LncRNA FTX in cancer progression. •LncRNA FTX is aberrantly expressed in cancer.•LncRNA FTX regulates tumor progression in various ways.•LncRNA FTX may be a novel therapeutic target for cancer treatment.