Highly Active La(III)‐Based Metal‐Organic Framework as a Heterogeneous Lewis Acid Catalyst for Friedel‐Crafts Alkylation

In this study, a novel La(III)‐based two‐dimensional (2D) metal‐organic framework, [La2/3(qptca)1/2] (referred to as SLX‐2), from LaCl3 and 1,1′ : 4′,1′′ : 4′′,1′′′ : 4′′′,1′′′′‐quinquephenyl]‐2,2′′,2′′′′,5′′‐tetracarboxylic acid (H4qptca) was synthesized by conventional solvothermal method and thoroughly characterized by using X‐ray single‐crystal diffraction, powder X‐ray diffraction, and thermogravimetric analyses. The 2D SLX‐2 features a unique lanthanum center exposed to the skeleton and was used as an efficient Lewis acid catalyst for the Friedel‐Crafts alkylation of indole and pyrrole with β‐nitrostyrene along with a wide substrate scope, giving the desired products in good‐to‐high yields under the optimal reaction conditions. Furthermore, the catalyst was used for twenty cycles, with nearly no effect on its activity, and the reaction was heterogeneous in nature. Moreover, compared to the previous hydrogen‐bond‐donating MOF catalysts for such alkylation reactions, SLX‐2 showed an excellent stability toward harsh acidic and basic environment, and gave comparable catalytic activities. A novel La(III)‐based two‐dimensional (2D) metal‐organic framework, [La2/3(qptca)1/2] was successfully synthesized from LaCl3 and 1,1′ : 4′,1′ ′: 4′′,1′′′ : 4′′′,1′′′′‐quinquephenyl]‐2,2′′,2′′′′,5′′‐tetracarboxylic acid (H4qptca) by conventional solvothermal method. Initial studies showed that it was an efficient heterogeneous catalyst for the Friedel‐Crafts alkylation of indole and pyrrole with β‐nitrostyrene with a wide substrate scope.