Battle of the γδ T cell subsets in the gut

In a study in Science, Reis et al. describe a temporal segregation of γδ T cell activities in colorectal cancer (CRC). Initially tumor surveillance is orchestrated by interferon-γ (IFN-γ)-producing and cytotoxic γδ T cell subsets, but once the tumor thrives, it becomes infiltrated by interleukin (IL...

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Veröffentlicht in:	Trends in Cancer 2022-11, Vol.8 (11), p.881-883
Hauptverfasser:	Mensurado, Sofia, Silva-Santos, Bruno
Format:	Artikel
Sprache:	eng
Schlagworte:	Humans Interferon-gamma Neoplasms Receptors, Antigen, T-Cell, gamma-delta T-Lymphocyte Subsets
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	In a study in Science, Reis et al. describe a temporal segregation of γδ T cell activities in colorectal cancer (CRC). Initially tumor surveillance is orchestrated by interferon-γ (IFN-γ)-producing and cytotoxic γδ T cell subsets, but once the tumor thrives, it becomes infiltrated by interleukin (IL)-17 γδ T cell subsets that promote its growth.
ISSN:	2405-8033 2405-8025
DOI:	10.1016/j.trecan.2022.08.006