Finding a chaperone for TDP-43

Aggregation of the RNA-binding protein TDP-43 is commonly observed in neurodegenerative disorders. A new study reveals that this process may be blocked by HSPB1, a small heat shock protein that can also regulate TDP-43 phase separation. This may be relevant to neurodegeneration, as loss of HSPB1 cor...

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Veröffentlicht in:	Nature cell biology 2022-09, Vol.24 (9), p.1328-1330
Hauptverfasser:	Ayala, Yuna M., Grese, Zachary R.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45/612/1230 631/80/304 631/80/470/1981 631/80/470/2284 Amyotrophic lateral sclerosis Biology Biomedical and Life Sciences Biosynthesis Cancer Research Cell Biology Cytoplasm Dementia Developmental Biology DNA-Binding Proteins - genetics Heat shock proteins Life Sciences Localization Molecular Chaperones - genetics Mutation Neurodegeneration Neurodegenerative diseases News & Views news-and-views Oxidative stress Pathology Phase separation RNA-binding protein Stem Cells
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Beschreibung
Zusammenfassung:	Aggregation of the RNA-binding protein TDP-43 is commonly observed in neurodegenerative disorders. A new study reveals that this process may be blocked by HSPB1, a small heat shock protein that can also regulate TDP-43 phase separation. This may be relevant to neurodegeneration, as loss of HSPB1 correlates with TDP-43 pathology.
ISSN:	1465-7392 1476-4679
DOI:	10.1038/s41556-022-00987-9