T-Cell Responses Against Mycobacterium ulcerans and Mycobacterium tuberculosis Protein Extracts Identify Children With Buruli Ulcer Disease

T-Cell Responses Against Mycobacterium ulcerans and Mycobacterium tuberculosis Protein Extracts Identify Children With Buruli Ulcer Disease

Immune-based diagnosis of Buruli ulcer disease (BUD) in children is difficult due to cross-reactivity between mycobacteria. We found that T-cell IFNγ/TNFα responses against Mycobacterium (M.) ulcerans and M. tuberculosis (PPDMulc, PPDMtub) were different between children with BUD (n = 27) and TB (n ...

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Veröffentlicht in:Journal of the Pediatric Infectious Diseases Society 2022-12, Vol.11 (12), p.575-577
Hauptverfasser: Jacobsen, Marc, Adjei, Jonathan Kofi, Aniagyei, Wilfred, Adankwah, Ernest, Seyfarth, Julia, Mayatepek, Ertan, Antwi-Berko, Daniel, Sakyi, Samuel Asamoah, Debrah, Alexander Y, Debrah, Linda Batsa, Owusu, Dorcas O, Phillips, Richard O
Format: Artikel
Sprache:eng
Schlagworte:
Buruli Ulcer - diagnosis
Buruli Ulcer - microbiology
Child
Humans
Mycobacterium tuberculosis
Mycobacterium ulcerans
T-Lymphocytes
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Zusammenfassung:Immune-based diagnosis of Buruli ulcer disease (BUD) in children is difficult due to cross-reactivity between mycobacteria. We found that T-cell IFNγ/TNFα responses against Mycobacterium (M.) ulcerans and M. tuberculosis (PPDMulc, PPDMtub) were different between children with BUD (n = 27) and TB (n = 20) but only ratios (PPDMtub/PPDMulc) discriminated the study groups efficiently.
ISSN:2048-7207
2048-7207
DOI:10.1093/jpids/piac092