Bioaccessibility of phenolic compounds in Psidium guajava L. varieties and P. friedrichsthalianum Nied. after gastrointestinal digestion

[Display omitted] •In vitro Psidium species bioaccesibility of phenolic compounds (PC) were 37 to 47%•Psidium friedrichsthalianum Nied. showed the highest PC content.•57 bioactive compounds were identified: PC, terpenoids and benzophenones.•Caffeoylquinic acid, ellagic acid & myricetin-3-O-rhamnoside were bioaccessible.•Prodelphinidin B2 isomer, galloyl-hexoside and cafeoylquimic acid were non-bioaccessible. Psidium guajava L. and Psidium friedrichsthalianum Nied are part of the Psidium species native to America. Nowadays, it is essential to study the phenolic compound (PC) profile and their changes during digestion and the fractions available for absorption. This study aimed to characterize the PC profile in some Psidium species and their bioaccessibility (BA). Fifty-seven compounds were identified, and forty-six belonged to ten different phenolic classes. PC profiles showed significant differences between the species and the intestinal fraction P. friedrichsthalianum Nied. showed the highest PC content, although it mostly belonged to non-extractable polyphenols. This leads to the lowest BA (37%); P. guajava L. ‘Morada’ showed the highest (47%). Hydroxycinnamic acids were the most stable PC after gastrointestinal digestion. This study showed relevant differences in the PC content and profile of different Psidium species and changes between the PC in the original matrix and those released in the different stages of gastrointestinal digestion.