Do bone turnover markers reflect changes in bone microarchitecture during treatment of patients with thyroid dysfunction?

Purpose This study aimed to compare changes in the bone turnover markers (BTMs)—C-terminal telopeptide of type I collagen (CTX-I) and procollagen I N-terminal peptide (PINP)—with changes in the bone microarchitecture, assessed by high-resolution peripheral quantitative computed tomography (HR-pQCT), during treatment of patients with thyroid dysfunction. Methods In women with newly diagnosed hypo- or hyperthyroidism, HR-pQCT variables, obtained from the tibia and the radius, were compared with BTMs. Data were collected at diagnosis and after at least 12 months of euthyroidism. Results 73 women completed the study (hypothyroidism, n = 27; hyperthyroidism, n = 46). Among hyperthyroid patients, correlations were found between changes in BTMs and HR-pQCT variables, primarily for cortical variables in the tibia, i.e. cortical thickness (CTX-I, p